Not all adult female black widows exhibit the red hourglass on their abdomen—some may have a pair of red spots or have no marking at all, but any markings that are present are bright red. Adult male black widows are a quarter the size of the female, and are usually gray or brown rather than black and red; while they may sometimes have an hourglass marking on their abdomen, it is usually yellow or white, not red. The bite of a male black widow is not considered dangerous to humans; it is the bite of the adult female black widow from her much larger venom sacs that has given this spider its dangerous reputation. While there is great variation in specifics by species and by gender, any spider exhibiting a red hourglass on the abdomen and having a shiny black body is an adult female black widow.
The southern black widow, as well as the closely related western and northern species which were previously considered the same species, has a prominent red hourglass figure on the underside of its abdomen. Many of the other widow spiders have red patterns on a glossy black or dark background, which serve as a warning.
Although these spiders are not especially large, their venom is extremely potent. Compared to many other species of spiders, their chelicerae are not very large or powerful. In the case of a mature female, the hollow, needle shaped part of each chelicera, the part that penetrates the skin, is approximately 1.0 millimeters (about 0.04 in) long, long enough to inject the venom to a point where it can be harmful. The males, being much smaller, inject far less venom with smaller chelicerae. The actual amount injected, even by a mature female, is very small in physical volume. When this small amount of venom is diffused throughout the body of a healthy, mature human, it usually does not amount to a fatal dose (though it can produce the very unpleasant symptoms of latrodectism).
Deaths in healthy adults from Latrodectus bites are relatively rare in terms of the number of bites per thousand people. Sixty-three deaths were reported in the United States between 1950 and 1959. On the other hand, the geographical range of the widow spiders is very great. As a result, far more people are exposed, worldwide, to widow bites than to bites of more dangerous spiders, so the highest number of deaths worldwide are caused by members of their genus. Widow spiders have more potent venom than most spiders, and prior to the development of antivenom, 5% of reported bites resulted in fatalities. The venom can cause a swelling up to 15 cm.